posted on 2024-03-11, 16:15authored byYingying Pan, Jingqin Chen, Yuling Zhang, Yaguang Ren, Zhifeng Wu, Qiang Xue, Silue Zeng, Chihua Fang, Hai Zhang, Lingyan Zhang, Chengbo Liu, Jie Zeng
Neuroinflammation is a significant pathological event
involving
the neurodegenerative process associated with many neurological disorders.
Diagnosis and treatment of neuroinflammation in its early stage are
essential for the prevention and management of neurological diseases.
Herein, we designed macrophage membrane-coated photoacoustic (PA)
probes (MSINPs), with targeting specificities based on naturally existing
target–ligand interactions for the early diagnosis of neuroinflammation.
The second near-infrared dye, IR1061, was doped into silica as the
core and was encapsulated with a macrophage membrane. In vitro as well as in vivo, the MSINPs could target inflammatory
cells via the inflammation chemotactic effect. PA imaging was used
to trace the MSINPs in a neuroinflammation mouse model and showed
a great targeted effect of MSINPs in the prefrontal cortex. Therefore,
the biomimetic nanoprobe prepared in this study offers a new strategy
for PA molecular imaging of neuroinflammation, which can enhance our
understanding of the evolution of neuroinflammation in specific brain
regions.