np0c00447_si_001.pdf (2.23 MB)
Secoiridoids and Iridoids from Morinda asteroscepa
journal contribution
posted on 2020-08-27, 19:42 authored by Linda Zandi, Marco Makungu, Joan J. E. Munissi, Sandra Duffy, Rakesh Puttreddy, Daniel von der Heiden, Kari Rissanen, Vicky M. Avery, Stephen S. Nyandoro, Máté ErdélyiThe new 2,3-secoiridoids morisecoiridoic
acids A (1) and B (2), the new iridoid 8-acetoxyepishanzilactone
(3), and four additional known iridoids (4–7) were isolated from the leaf and stem bark
methanol extracts of Morinda asteroscepa using chromatographic
methods. The structure of shanzilactone (4) was revised.
The purified metabolites were identified using NMR spectroscopic and
mass spectrometric techniques, with the absolute configuration of 1 having been established by single-crystal X-ray diffraction
analysis. The crude leaf extract (10 μg/mL) and compounds 1–3 and 5 (10 μM) showed
mild antiplasmodial activities against the chloroquine-sensitive malaria
parasite Plasmodium falciparum (3D7).