American Chemical Society
np034035z_si_001.pdf (2.73 MB)

Scleritodermin A, a Cytotoxic Cyclic Peptide from the Lithistid Sponge Scleritoderma nodosum

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journal contribution
posted on 2004-03-26, 00:00 authored by Eric W. Schmidt, Carmen Raventos-Suarez, Marc Bifano, Ana T. Menendez, Craig R. Fairchild, D. John Faulkner
The lithistid sponge Scleritoderma nodosum contains a new cyclic peptide, scleritodermin A (1), the structure of which incorporates l-proline, l-serine, and keto-allo-isoleucine units as well as a novel conjugated thiazole moiety (ACT) and O-methyl-N-sulfoserine. Scleritodermin A (1) inhibited tubulin polymerization and showed significant in vitro cytotoxicity against human tumor cell lines.