posted on 2004-03-26, 00:00authored byEric W. Schmidt, Carmen Raventos-Suarez, Marc Bifano, Ana T. Menendez, Craig R. Fairchild, D. John Faulkner
The lithistid sponge Scleritoderma nodosum contains a new cyclic peptide, scleritodermin A (1), the
structure of which incorporates l-proline, l-serine, and keto-allo-isoleucine units as well as a novel
conjugated thiazole moiety (ACT) and O-methyl-N-sulfoserine. Scleritodermin A (1) inhibited tubulin
polymerization and showed significant in vitro cytotoxicity against human tumor cell lines.