Scalarane-Based Sesterterpenoid RCE-Protease Inhibitors Isolated from the Indonesian Marine Sponge Carteriospongia foliascens
journal contributionposted on 26.06.2009, 00:00 by David E. Williams, Irwin Hollander, Larry Feldberg, Eileen Frommer, Robert Mallon, Akbar Tahir, Rob van Soest, Raymond J. Andersen
Two new 20,24-bishomo-25-norscalaranes, compounds 1 and 2, and two new and two known 20,24-bishomoscalaranes, compounds 3−6, have been isolated from the Indonesian marine sponge Carteriospongia foliascens. The structures of 1−6 were determined by spectroscopic analysis. Compounds 1 and 3−6 inhibit RCE-protease activity.