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Scalable Synthesis of Anomerically Pure Orthogonal-Protected GlcN3 and GalN3 from d‑Glucosamine

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journal contribution
posted on 23.08.2016, 13:07 authored by Emil Glibstrup, Christian Marcus Pedersen
An improved and scalable synthesis of orthogonally protected d-glucosamine and d-galactosamine building blocks from inexpensive d-glucosamine has been developed. The key reaction is an inversion/migration step providing access to a fully orthogonal protecting group pattern, which is required for microbial oligosaccharide synthesis. The method can be carried out on a multigram scale as several of the reactions can be purified by crystallization to give anomerically pure products.

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