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Scaffolded DNA Origami of a DNA Tetrahedron Molecular Container

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journal contribution
posted on 10.06.2009, 00:00 by Yonggang Ke, Jaswinder Sharma, Minghui Liu, Kasper Jahn, Yan Liu, Hao Yan
We describe a strategy of scaffolded DNA origami to design and construct 3D molecular cages of tetrahedron geometry with inside volume closed by triangular faces. Each edge of the triangular face is ∼54 nm in dimension. The estimated total external volume and the internal cavity of the triangular pyramid are about 1.8 × 10−23 and 1.5 × 10−23 m3, respectively. Correct formation of the tetrahedron DNA cage was verified by gel electrophoresis, atomic force microscopy, transmission electron microscopy, and dynamic light scattering techniques.