ol5027014_si_001.pdf (2.08 MB)
Sc(OTf)3‑Catalyzed Transfer Diazenylation of 1,3-Dicarbonyls with Triazenes via N–N Bond Cleavage
journal contributionposted on 2014-10-17, 00:00 authored by Cong Liu, Jian Lv, Sanzhong Luo, Jin-Pei Cheng
A new and efficient method for diazenylation reactions was developed with a Sc(OTf)3-catalyzed nitrogen–nitrogen bond cleavage process with triazenes. The transfer diazenylation reactions accommodate a diverse range of active methylene substrates including simple ketones to give aliphatic azo compounds that are of significant potential as azo prodrugs in high yields under mild conditions.