Sacchathridine A (1)
was isolated from the fermentation
broth of strain Saccharothrix sp. MI559-46F5. The
structure was determined as a new naphthoquinone derivative with an
acetylhydrazino moiety by a combination of NMR, MS spectral analyses,
and chemical degradation. Compound 1 showed inhibitory
activity of prostaglandin E2 release in a concentration-dependent
manner from human synovial sarcoma cells, SW982, with an IC50 value of 1.0 μM, but had no effect on cell growth up to 30
μM.