American Chemical Society
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Sacchathridine A, a Prostaglandin Release Inhibitor from Saccharothrix sp.

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journal contribution
posted on 2013-04-26, 00:00 authored by Koichi Nakae, Ikuko Kurata, Fukiko Kojima, Masayuki Igarashi, Masaki Hatano, Ryuichi Sawa, Yumiko Kubota, Hayamitsu Adachi, Akio Nomoto
Sacchathridine A (1) was isolated from the fermentation broth of strain Saccharothrix sp. MI559-46F5. The structure was determined as a new naphthoquinone derivative with an acetylhydrazino moiety by a combination of NMR, MS spectral analyses, and chemical degradation. Compound 1 showed inhibitory activity of prostaglandin E2 release in a concentration-dependent manner from human synovial sarcoma cells, SW982, with an IC50 value of 1.0 μM, but had no effect on cell growth up to 30 μM.