Sacchathridine
A, a Prostaglandin Release Inhibitor
from Saccharothrix sp.

Nakae, Koichi; Kurata, Ikuko; Kojima, Fukiko; Igarashi, Masayuki; Hatano, Masaki; Sawa, Ryuichi; Kubota, Yumiko; Adachi, Hayamitsu; Nomoto, Akio

doi:10.1021/np3006327.s001

np3006327_si_001.pdf (338.04 kB)

Sacchathridine A, a Prostaglandin Release Inhibitor from Saccharothrix sp.

journal contribution

posted on 2013-04-26, 00:00 authored by Koichi Nakae, Ikuko Kurata, Fukiko Kojima, Masayuki Igarashi, Masaki Hatano, Ryuichi Sawa, Yumiko Kubota, Hayamitsu Adachi, Akio Nomoto

Sacchathridine A (1) was isolated from the fermentation broth of strain Saccharothrix sp. MI559-46F5. The structure was determined as a new naphthoquinone derivative with an acetylhydrazino moiety by a combination of NMR, MS spectral analyses, and chemical degradation. Compound 1 showed inhibitory activity of prostaglandin E₂ release in a concentration-dependent manner from human synovial sarcoma cells, SW982, with an IC₅₀ value of 1.0 μM, but had no effect on cell growth up to 30 μM.