jo500222d_si_001.pdf (439.67 kB)
SET-Induced Biaryl Cross-Coupling: An SRN1 Reaction
journal contributionposted on 2015-12-17, 01:09 authored by Brandon E. Haines, Olaf Wiest
The SET-induced biaryl cross-coupling reaction is established as the first example of a Grignard SRN1 reaction. The reaction is examined within the mechanistic framework of dissociative electron transfer in the presence of a Lewis acid. DFT calculations show that the reaction proceeds through a radical intermediate in the form of an Mg ion-radical cage, which eludes detection in trapping experiments by reacting quickly to form an MgPh2 radical anion intermediate. A new mechanism is proposed.