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Ruthenium(II)-Catalyzed Regioselective Reductive Coupling of α‑Imino Esters with Dienes

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journal contribution
posted on 19.02.2016, 13:42 by Shujie Zhu, Xiaoxia Lu, Yueting Luo, Wei Zhang, Huanfeng Jiang, Ming Yan, Wei Zeng
A method for the highly regioselective reductive coupling reaction of N-aryl-α-imino esters with dienes is described. The method utilizes the RuHCl(CO)(PPh3)3/iPrOH catalytic system under an Ar atmosphere and provides α-branched allylic α-amino acid derivatives. Application of this transformation to the concise synthesis of a natural plant growth regulator is demonstrated.