ol4006079_si_001.pdf (5.84 MB)
Download file

Ruthenium(II)-Catalyzed Regioselective Reductive Coupling of α‑Imino Esters with Dienes

Download (5.84 MB)
journal contribution
posted on 19.02.2016, 13:42 by Shujie Zhu, Xiaoxia Lu, Yueting Luo, Wei Zhang, Huanfeng Jiang, Ming Yan, Wei Zeng
A method for the highly regioselective reductive coupling reaction of N-aryl-α-imino esters with dienes is described. The method utilizes the RuHCl(CO)(PPh3)3/iPrOH catalytic system under an Ar atmosphere and provides α-branched allylic α-amino acid derivatives. Application of this transformation to the concise synthesis of a natural plant growth regulator is demonstrated.

History