ol0c02024_si_001.pdf (2.07 MB)
Ruthenium(II)-Catalyzed Regioselective [3 + 2] Spiroannulation of 2H‑Imidazoles with 2‑Alkynoates
journal contribution
posted on 2020-08-12, 16:36 authored by Zhenyu Song, Zi Yang, Pu Wang, Zhaojiang Shi, Tingfang Li, Xiuling CuiThe CN double
bond of 2H-imidazole has
been employed as a C-electrophile for the ruthenium(II)-catalyzed
[3 + 2] spiroannulation reaction of 4-phenyl-2H-imidazoles
and 2-alkynoates to synthesize spiroimidazole-4,1′-indenes.
This strategy features high regioselectivity, broad functional group
tolerance, and use of ruthenium as a catalyst, providing a new method
to synthesize spirocycles with potential applications in pharmaceuticals.