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Ruthenium(III)-Catalyzed β‑Alkylation of Secondary Alcohols with Primary Alcohols

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journal contribution
posted on 21.04.2016, 13:06 authored by Qingfu Wang, Kaikai Wu, Zhengkun Yu
A Ru­(III)-NNN complex bearing a pyridyl-supported pyrazolyl-imidazolyl ligand was synthesized and utilized as the catalyst for the direct β-alkylation of secondary alcohols with primary alcohols. β-Alkylated secondary alcohols were obtained in moderate to high yields with water formed as the byproduct through a hydrogen borrowing pathway. The present protocol provides a concise atom-economical and environmentally benign method for C–C bond formation.