Ruthenium(III)-Catalyzed β‑Alkylation of Secondary Alcohols with Primary Alcohols
journal contributionposted on 21.04.2016 by Qingfu Wang, Kaikai Wu, Zhengkun Yu
Any type of content formally published in an academic journal, usually following a peer-review process.
A Ru(III)-NNN complex bearing a pyridyl-supported pyrazolyl-imidazolyl ligand was synthesized and utilized as the catalyst for the direct β-alkylation of secondary alcohols with primary alcohols. β-Alkylated secondary alcohols were obtained in moderate to high yields with water formed as the byproduct through a hydrogen borrowing pathway. The present protocol provides a concise atom-economical and environmentally benign method for C–C bond formation.