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Ruthenium-Catalyzed ortho-Alkenylation of Phenylphosphine Oxides through Regio- and Stereoselective Alkyne Insertion into C–H Bonds

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journal contribution
posted on 16.08.2013, 00:00 by Masaki Itoh, Yuto Hashimoto, Koji Hirano, Tetsuya Satoh, Masahiro Miura
Direct ortho-substitution took place efficiently upon treatment of tri-, di-, and monoarylphosphine oxides with internal alkynes in the presence of a ruthenium catalyst to produce (o-alkenylphenyl)­phosphine oxides regio- and stereoselectively. Chemoselective reduction of a product gave the corresponding (o-alkenylphenyl)­phosphine, which may be useful as a ligand for transition metals.