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Ruthenium-Catalyzed Alkylation of Oxindole with Alcohols

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journal contribution
posted on 15.05.2009, 00:00 by Thomas Jensen, Robert Madsen
An atom-economical and solvent-free catalytic procedure for the mono-3-alkylation of oxindole with alcohols is described. The reaction is mediated by the in situ generated catalyst from RuCl3·xH2O and PPh3 in the presence of sodium hydroxide. The reactions proceed in good to excellent yields with a wide range of aromatic, heteroaromatic, and aliphatic alcohols.