ja7b04564_si_001.pdf (8.4 MB)
Ruthenium-Catalyzed Cycloisomerization of 2‑Alkynylanilides: Synthesis of 3‑Substituted Indoles by 1,2-Carbon Migration
journal contribution
posted on 2017-05-24, 00:00 authored by Takuma Watanabe, Yuichiro Mutoh, Shinichi SaitoWe developed ruthenium-catalyzed
cycloisomerization of alkynylanilides
that gave 3-substituted indoles in high yields. The reaction proceeded
via the disubstituted vinylidene ruthenium complex that was formed
by the 1,2-carbon migration.