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Rubesanolides A and B: Diterpenoids from Isodon rubescens

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journal contribution
posted on 18.03.2011, 00:00 by Juan Zou, Lutai Pan, Qiji Li, Junhua Zhao, Jianxin Pu, Ping Yao, Ningbo Gong, Yang Lu, Tamara P. Kondratyuk, John M. Pezzuto, Harry H. S. Fong, Hongjie Zhang, Handong Sun
From the medicinal plant Isodon rubescens, we isolated two novel diterpenes, rubesanolides A (1) and B (2). The compounds contain a unique β-lactone subgroup. This is the first discovery for a natural diterpene having rings A, B, and C in chair, boat, and twist-chair conformations, respectively. The structures were elucidated by analysis of spectroscopic data, and the absolute configuration of 1 was determined by X-ray diffraction.