jo5b00316_si_001.pdf (4.43 MB)

Ru(II)-Catalyzed Oxidative Spiroannulation of 2‑Arylphenols with Alkynes via a C–H Activation/Dearomatization Strategy

Download (4.43 MB)
journal contribution
posted on 20.03.2015, 00:00 by Zhijun Zuo, Xin Yang, Jingjing Liu, Jiang Nan, Lu Bai, Yaoyu Wang, Xinjun Luan
An intermolecular spiroannulation reaction of appropriately substituted 2-arylphenols with internal alkynes has been developed by using a Ru­(II) catalyst and an oxidant. This transformation was realized by a phenol-directed C–H activation, migratory insertion of the alkyne, and subsequent dearomatization of the phenolic ring, providing a broad range of highly functionalized spirocyclic compounds in moderate yields with high regioselectivity.