posted on 2024-03-07, 20:41authored byQiaoya Zhang, Yinling Li, Yabo Chen, Jiahua Jiang, Yuan Liu, Jiye Luo, Yang Gao, Yanping Huo, Qian Chen, Xianwei Li
Native functionality directed the
C–H activation
cascade
to enable rapid construction of molecular complexity, featuring step-economy
and synthetic efficiency. Herein, by exploiting bifunctional α-alcohol
haloalkynes, we developed Ru(II)-catalyzed carboxylic acid, amine,
and amide assisted divergent C–H alkynylation and annulation
cascade, affording polyfunctional heterocycles. Significantly, a bilateral
aryl C–H polycyclization cascade of azobenzenes was achieved
using the versatile haloalkynes.