American Chemical Society
om1c00264_si_001.pdf (4.76 MB)

Ru-Catalyzed Site-Selective Aliphatic C–H Bond Silylation of Amides and Carbamides

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journal contribution
posted on 2021-07-13, 16:15 authored by Xin Zhang, Peiyu Geng, Guixia Liu, Zheng Huang
Hydrido ruthenium complexes (POCNP)­RuH­(NBD) (NBD = norbornadiene) supported by N/O-bridged pincer ligands have been synthesized and characterized. The Ru complex containing a pincer ligand with an indolol scaffold exhibits high catalytic activity for the intermolecular aliphatic C–H bond silylation of amides and carbamides. The reaction proceeds selectively at the C–H bonds adjacent to the nitrogen atom to efficiently afford α-silyl amides and carbamides.