Ru-Catalyzed Site-Selective Aliphatic C–H Bond Silylation of Amides and Carbamides

Hydrido ruthenium complexes (POCNP)­RuH­(NBD) (NBD = norbornadiene) supported by N/O-bridged pincer ligands have been synthesized and characterized. The Ru complex containing a pincer ligand with an indolol scaffold exhibits high catalytic activity for the intermolecular aliphatic C–H bond silylation of amides and carbamides. The reaction proceeds selectively at the C–H bonds adjacent to the nitrogen atom to efficiently afford α-silyl amides and carbamides.