ol502030y_si_001.pdf (4.41 MB)
Download file

Room-Temperature Direct Alkynylation of Arenes with Copper Acetylides

Download (4.41 MB)
journal contribution
posted on 05.09.2014, 00:00 by Cédric Theunissen, Gwilherm Evano
C–H bond in azoles and polyhalogenated arenes can be smoothly activated by copper acetylides to give the corresponding alkynylated (hetero)­arenes by simple reaction at room temperature in the presence of phenanthroline and lithium tert-butoxide under an oxygen atmosphere. These stable, unreactive, and readily available polymers act as especially efficient and practical reagents for the introduction of an alkyne group to a wide number of arenes under remarkably mild conditions.