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Room-Temperature Direct Alkynylation of Arenes with Copper Acetylides

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journal contribution
posted on 05.09.2014, 00:00 by Cédric Theunissen, Gwilherm Evano
C–H bond in azoles and polyhalogenated arenes can be smoothly activated by copper acetylides to give the corresponding alkynylated (hetero)­arenes by simple reaction at room temperature in the presence of phenanthroline and lithium tert-butoxide under an oxygen atmosphere. These stable, unreactive, and readily available polymers act as especially efficient and practical reagents for the introduction of an alkyne group to a wide number of arenes under remarkably mild conditions.

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