Room-Temperature Pd-Catalyzed Synthesis of 1‑(Hetero)aryl Selenoglycosides
journal contributionposted on 06.08.2020 by Mingxiang Zhu, Mouad Alami, Samir Messaoudi
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A general protocol for functionalization of an anomeric selonate anion at room temperature has been reported. By using the PdG3 XantPhos catalyst, the cross-coupling between the in situ-generated glycosyl selenolate and a broad range of (hetero)aryl and alkenyl iodides furnished a series of functionalized selenoglycosides in excellent yields with perfect control of the anomeric configuration.