Ring-Opening Diarylation of Siloxydifluorocyclopropanes by Ag(I) Catalysis: Stereoselective Construction of 2‑Fluoroallylic Scaffold
journal contribution
posted on 2017-12-05, 18:48 authored by Xiaoning Song, Cong Xu, Dongxu Du, Ziming Zhao, Dongsheng Zhu, Mang WangA silver-catalyzed, defluorination
ring-opening diarylation of
siloxy 2,2-difluorocyclopropanes, with two arenes, to directly prepare
polysubstituted 2-fluoroallylic compounds, is described. This multicomponent
reaction proceeds smoothly in good stereoselectivity, which is due
to a chelation-controlled addition of arenes to α-fluorinated
ketone intermediate.
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polysubstituted 2- fluoroallylic compoundsScaffoldSiloxydifluorocyclopropaneCatalysisiloxydefluorination ring-opening diarylationmulticomponent reaction proceedsstereoselectivitysilver-catalyzeddifluorocyclopropaneareneStereoselective ConstructionAgketoneRing-Opening DiarylationFluoroallylicα-chelation-controlled addition
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