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Rhodium(III)-Catalyzed Selective Monoarylation of β or γ C(sp3)–H Bonds Assisted by a Trimethylpyrazole Group

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journal contribution
posted on 30.12.2016, 15:52 authored by Chunchen Yuan, Guangliang Tu, Yingsheng Zhao
The selective arylation of unactivated β or challenging γ primary and secondary β-C­(sp3)–H bonds has been developed with a Cp*Rh­(III) catalyst assisted by a trimethylpyrazole group. A rarely reported six-membered rhodacycle has been identified in rhodium-catalyzed C­(sp3)–H activation reactions. Preliminary mechanistic studies have revealed that a concerted metalation–deprotonation pathway might be involved in the C–H activation step.