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Rhodium(III)-Catalyzed C(sp3)–H Alkylation of 8‑Methylquinolines with Maleimides

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journal contribution
posted on 31.08.2016, 16:36 by Sangil Han, Jihye Park, Saegun Kim, Suk Hun Lee, Satyasheel Sharma, Neeraj Kumar Mishra, Young Hoon Jung, In Su Kim
The rhodium­(III)-catalyzed cross-coupling reaction of 8-methylquinolines and maleimides is described. In contrast to the C­(sp2)–H functionalization, a first catalytic functionalization of sp3 C–H bonds with maleimides is reported. This protocol provides a facile access to various succinimide scaffolds on 8-methylquinolines via a direct C–H cleavage approach.