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Rhodium-Catalyzed and Zinc(II)-Triflate-Promoted Asymmetric Hydrogenation of Tetrasubstituted α,β-Unsaturated Ketones

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journal contribution
posted on 2012-02-17, 00:00 authored by Joel R. Calvin, Michael O. Frederick, Dana L. T. Laird, Jacob R. Remacle, Scott A. May
The asymmetric hydrogenation of tetrasubstituted α,β-unsaturated ketones has been accomplished using an in situ formed rhodium-Josiphos catalyst. The reaction is enhanced by addition of catalytic zinc(II) triflate, which significantly improves turnover frequency while suppressing epimerization of the products.

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