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Rhodium-Catalyzed Novel Trifluoromethylation at the α-Position of α,β-Unsaturated Ketones

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journal contribution
posted on 11.11.2004, 00:00 by Kazuyuki Sato, Masaaki Omote, Akira Ando, Itsumaro Kumadaki
Treatment of α,β-unsaturated ketones with CF3I in the presence of Et2Zn and RhCl(PPh3)3 gave novel α-trifluoromethylation products in good yields. Hydrogen transfer from the ethyl group on the rhodium complex to the β-position of the enone seems to play an important role in this reaction.

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