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Rhodium-Catalyzed Remote Isomerization of Alkenyl Alcohols to Ketones

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journal contribution
posted on 06.02.2020, 13:04 by Wenke Dong, Hongxuan Yang, Wen Yang, Wanxiang Zhao
We develop herein an efficient rhodium-catalyzed remote isomerization of aromatic and aliphatic alkenyl alcohols into ketones. This catalytic process, with a commercially available catalyst and ligand ([RhCl­(cod)]2 and Xantphos), features high efficiency, low catalyst loading, good functional group tolerance, a broad substrate scope, and no (sub)­stoichiometric additive. Preliminary mechanistic studies suggest that this transformation involves an iterative dissociative β-hydride elimination–migration insertion process.