American Chemical Society
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Rhodium-Catalyzed Annulation of Primary Benzylamine with α‑Diazo Ketone toward Isoquinoline

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journal contribution
posted on 2016-08-12, 00:00 authored by Haoke Chu, Peiran Xue, Jin-Tao Yu, Jiang Cheng
Rhodium-catalyzed annulation of commercially available primary benzylamine with α-diazo ketone was developed, leading to isoquinolines in moderate to good yields. This procedure features the employment of primary benzylamine as starting material as well as high selectivity in the 3- and 4- position of isoquinoline, generating a key compliment to the previously developed annulation with internal alkyne.