American Chemical Society
jo8b01835_si_001.pdf (5.43 MB)

Rhodium-Catalyzed Annulation of α‑Imino Carbenes with α,β-Unsaturated Ketones: Construction of Multisubstituted 2,3-Dihydropyrrole/pyrrole Rings

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journal contribution
posted on 2018-11-06, 00:00 authored by Xueji Ma, Li Liu, Jiaying Wang, Xianglin Xi, Xuemei Xie, Hangxiang Wang
An efficient annulation of α-imino rhodium carbenes with α,β-unsaturated ketones has been developed to generate multisubstituted 2,3-dihydropyrrole derivatives. Using the optimized catalyst, this approach is compatible with both cyclic and normal linear α,β-unsaturated ketones. Further detosylation in the presence of base could produce multisubstituted pyrroles. The new method has the potential to enable the rapid construction of bioactive molecules containing pyrrole rings.