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Rh(I)-Catalyzed Direct ortho-Alkenylation of Aromatic Ketimines with Alkynes and Its Application to the Synthesis of Isoquinoline Derivatives

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journal contribution
posted on 02.07.2003, 00:00 by Sung-Gon Lim, Jun Hee Lee, Choong Woon Moon, Jun-Bae Hong, Chul-Ho Jun
Novel synthetic methods of both ortho-alkenylated aromatic ketones and isoquinoline derivatives have been developed through the Rh(I)-catalyzed direct ortho-alkenylation of common aromatic ketimines with alkynes. Furthermore, a highly efficient one-pot synthesis of isoquinoline derivatives was achieved by simply mixing aromatic ketone, benzylamine, and alkyne under a Rh(I) catalyst.