ol7b02135_si_001.pdf (1.87 MB)
Rh(I)-Catalyzed Alkylation of ortho-C–H Bonds in Aromatic Amides with Maleimides
journal contribution
posted on 2017-08-11, 20:29 authored by Qiyuan He, Takuma Yamaguchi, Naoto ChataniAn
alkylation of C–H bonds with maleimides by a rhodium-catalyzed
reaction of aromatic amides containing an 8-aminoquinoline moiety
as the directing group is reported. Various N-substituents
in the maleimide, including methyl, ethyl, cyclohexyl, benzyl, and
phenyl groups and even H, are applicable to the reaction. The reaction
is highly regioselective at the less hindered ortho-C–H bond when meta-substituted aromatic
amides are used as substrates.