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Rh(II)/Brønsted Acid Cocatalyzed Intramolecular Trapping of Ammonium Ylides with Enones: Diastereoselective Synthesis of 2,2,3-Trisubstituted Indolines

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journal contribution
posted on 05.09.2014, 00:00 by Liqin Jiang, Renqi Xu, Zhenghui Kang, Yixiao Feng, Fengxia Sun, Wenhao Hu
Highly diastereoselective intramolecular trapping of ammonium ylides with enones has been developed through a Rh­(II)/Brønsted acid cocatalytic strategy. This process allows rapid and efficient construction of N-unprotected polyfunctional 2,2,3-trisubstituted indolines in moderate to good yields with excellent diastereoselectivity.