Rh(III)-Catalyzed Redox-Neutral
Annulation of Primary
Benzamides with Diazo Compounds: Approach to Isoquinolinones

Wu, Youzhi; Sun, Peng; Zhang, Kaifan; Yang, Tie; Yao, Hequan; Lin, Aijun

doi:10.1021/acs.joc.5b02824.s001

jo5b02824_si_001.pdf (4.19 MB)

Rh(III)-Catalyzed Redox-Neutral Annulation of Primary Benzamides with Diazo Compounds: Approach to Isoquinolinones

journal contribution

posted on 2016-01-28, 00:00 authored by Youzhi Wu, Peng Sun, Kaifan Zhang, Tie Yang, Hequan Yao, Aijun Lin

Reported herein is a Rh-catalyzed redox-neutral annulation of primary benzamides with diazo compounds, representing an efficient and economic protocol to isoquinolinones. The procedure exhibited good functional group tolerability, scalability, and regioselectivity, obviating the need for oxidants, and only environmentally benign N₂ and H₂O were released. Further utilization of the method provided an alternative route to functionalized isoquinolines.