Rh(III)-Catalyzed Direct Coupling of Azobenzenes with
α‑Diazo Esters: Facile Synthesis of Cinnolin-3(2H)‑ones

Sharma, Satyasheel; Han, Sang Hoon; Han, Sangil; Ji, Wontae; Oh, Jongchan; Lee, Seok-Yong; Oh, Joa Sub; Jung, Young Hoon; Kim, In Su

doi:10.1021/acs.orglett.5b01298.s001

ol5b01298_si_001.pdf (2.67 MB)

Rh(III)-Catalyzed Direct Coupling of Azobenzenes with α‑Diazo Esters: Facile Synthesis of Cinnolin-3(2H)‑ones

journal contribution

posted on 2015-06-05, 00:00 authored by Satyasheel Sharma, Sang Hoon Han, Sangil Han, Wontae Ji, Jongchan Oh, Seok-Yong Lee, Joa Sub Oh, Young Hoon Jung, In Su Kim

The rhodium(III)-catalyzed direct C–H functionalization of azobenzenes with α-diazo compounds is described. These transformations provide the facile and efficient construction of C2-alkylated azobenzenes or highly substituted cinnolin-3(2H)-ones. Furthermore, this protocol leads to the formation of cinnolin-3(2H)-ones using a diazo derivative of Meldrum’s acid.