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Rh(III)-Catalyzed Decarboxylative ortho-Heteroarylation of Aromatic Carboxylic Acids by Using the Carboxylic Acid as a Traceless Directing Group

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journal contribution
posted on 03.04.2015, 00:00 by Xurong Qin, Denan Sun, Qiulin You, Yangyang Cheng, Jingbo Lan, Jingsong You
Highly selective decarboxylative ortho-heteroarylation of aromatic carboxylic acids with various heteroarenes has been developed through Rh­(III)-catalyzed two-fold C–H activation, which exhibits a wide substrate scope of both aromatic carboxylic acids and heteroarenes. The use of naturally occurring carboxylic acid as the directing group avoids troublesome extra steps for installation and removal of an external directing group.