Rh-Catalyzed General Method for Directed C–H Functionalization via Decarbonylation of in-Situ-Generated Acid Fluorides from Carboxylic Acids

A Rh-catalyzed decarbonylative C–H coupling of in-situ-generated acid fluorides with amide substrates bearing ortho-Csp²–H bonds has been developed. This method enables alkyl, aryl, and alkenyl carboxylic acids to undergo decarbonylative coupling with C–H bonds of (hetero)­aromatic or alkenyl amides in generally good yields via the in situ conversion of carboxylic acids into acid fluorides and also allows for the functionalization of a series of structurally complex carboxyl-containing natural products and pharmaceuticals as well as pharmaceutical amide derivatives.