Rh-Catalyzed Base-Free Decarbonylative Borylation of Twisted Amides
journal contributionposted on 30.10.2020, 12:58 by Fusheng Bie, Xuejing Liu, Yijun Shi, Han Cao, Ying Han, Michal Szostak, Chengwei Liu
We report the rhodium-catalyzed base-free decarbonylative borylation of twisted amides. The synthesis of versatile arylboronate esters from aryl twisted amides is achieved via decarbonylative rhodium(I) catalysis and highly selective N–C(O) insertion. The method is notable for a very practical, additive-free Rh(I) catalyst system. The method shows broad functional group tolerance and excellent substrate scope, including site-selective decarbonylative borylation/Heck cross-coupling via divergent N–C/C–Br cleavage and late-stage pharmaceutical borylation.