ja037167n_si_001.pdf (247.67 kB)

Reversible Electrochemical Detection of Nonelectroactive Polyions

Download (247.67 kB)
journal contribution
posted on 19.08.2003, 00:00 by Alexey Shvarev, Eric Bakker
Selective extraction principles for the recognition of nonelectroactive polyions such as heparin and protamine exist, but the high ionic valency renders the extraction process irreversible. A response principle for the reversible detection of such polyions is proposed here. The extraction of the polyionic analyte to the membrane and its subsequent back-extraction is now controlled electrochemically. The principle is established with a protamine electrode, and excellent stability and reproducibility are demonstrated. This method has important implications for the design of chemical recognition principles for polyionic analytes.