Resveratrol Oligomers from Vatica albiramis

Abe, Naohito; Ito, Tetsuro; Ohguchi, Kenji; Nasu, Minori; Masuda, Yuichi; Oyama, Masayoshi; Nozawa, Yoshinori; Ito, Masafumi; Iinuma, Munekazu

doi:10.1021/np1002675.s001

Resveratrol Oligomers from Vatica albiramis

journal contribution

posted on 2010-09-24, 00:00 authored by Naohito Abe, Tetsuro Ito, Kenji Ohguchi, Minori Nasu, Yuichi Masuda, Masayoshi Oyama, Yoshinori Nozawa, Masafumi Ito, Munekazu Iinuma

Five new stilbenoids, vatalbinosides A−E (1−5), and 13 known compounds (6−18) were isolated from the stem of Vatica albiramis. The effects of these new compounds on interleukin-1β-induced production of matrix metalloproteinase-1 (MMP-1) in human dermal fibroblasts were examined. Three resveratrol tetramers, (−)-hopeaphenol (6), vaticanol C (13), and stenophyllol C (14), were identified as strong inhibitors of MMP-1 production.