ol060330+_si_001.pdf (2.14 MB)
Resin-Bound Dynamic Combinatorial Chemistry
journal contribution
posted on 2006-04-27, 00:00 authored by Brian R. McNaughton, Benjamin L. MillerDynamic combinatorial chemistry (DCC) is a promising technique for receptor-aided selection of high-affinity ligands from equilibrating
combinatorial libraries. Identification of the specific ligand(s) selected is often challenging, however, due to difficulties associated with
chromatographic separation and/or mass degeneracy within the library. Herein, we describe proof-of-concept experiments demonstrating a
new technique termed resin-bound DCC (RB-DCC), which provides a solution to this problem.