American Chemical Society
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Remote Optical Switch for Localized and Selective Control of Gene Interference

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journal contribution
posted on 2009-02-11, 00:00 authored by Somin Eunice Lee, Gang Logan Liu, Franklin Kim, Luke P. Lee
Near infrared-absorbing gold nanoplasmonic particles (GNPs) are used as optical switches of gene interference and are remotely controlled using light. We have tuned optical switches to a wavelength where cellular photodamage is minimized. Optical switches are functionalized with double-stranded oligonucleotides. At desired times and at specific intracellular locations, remote optical excitation is used to liberate gene-interfering oligonucleotides. We demonstrate a novel gene-interfering technique offering spatial and temporal control, which is otherwise impossible using conventional gene-interfering techniques.