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Regiospecific Synthesis of 1,2-Disubstituted (Hetero)aryl Fused Imidazoles with Tunable Fluorescent Emission

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journal contribution
posted on 16.12.2011, 00:00 by Dongbing Zhao, Junyi Hu, Ningjie Wu, Xiaolei Huang, Xurong Qin, Jingbo Lan, Jingsong You
A palladium-catalyzed two or fourfold amination was established that allows regiospecific synthesis of a diversity-oriented library of 1,2-disubstituted (hetero)aryl fused imidazoles, and provides an exceptional tool for the discovery of fluorescent scaffolds with tunable fluorescence emission. These fluorophores have been applied as fluorescent probes for live cell imaging.