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Regiospecific Organocatalytic Asymmetric Aldol Reaction of Methyl Ketones and α,β-Unsaturated Trifluoromethyl Ketones

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journal contribution
posted on 29.03.2007, 00:00 by Xiao-Jin Wang, Yan Zhao, Jin-Tao Liu
The aldol reaction of methyl ketones and α,β-unsaturated trifluoromethyl ketones occurred under mild conditions with the combination of proline-derived N-sulfonylamide and trifluoroacetic acid as the catalyst to give the corresponding unsaturated α-trifluoromethyl tertiary alcohols in high yields with good enatioselectivities.