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Regioselective Synthesis of an Imidazo[4,5-c]pyridine through Selective Acylation of 3,4-Diaminopyridine:  Synthesis of CP-885,316

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journal contribution
posted on 17.03.2006, 00:00 by Stéphane Caron, Nga M. Do, Ruth E. McDermott, S. Bahmanyar
CP-885,316 (1), an imidazo[4,5-c]pyridine, 4, was prepared from 3,4-diaminopyridine (9). Two routes were demonstrated using the regioselective introduction of either an acetamide at the 3-position or a tert-butylcarbamate at the 4-position.