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Regioselective Synthesis of Fused Oxazepinone Scaffolds through One-Pot Smiles Rearrangement Tandem Reaction

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journal contribution
posted on 12.09.2011, 00:00 by Yanli Liu, Chunxiao Chu, Aiping Huang, Chunjing Zhan, Ying Ma, Chen Ma
The paper describes a convenient and facile methodology for the regioselective synthesis of fused oxazepinone scaffolds. This process is an efficient construction of the oxazepinone scaffold by a one-pot coupling/Smiles rearrangement/cyclization approach. This transition metal-free process has potential applications in the synthesis of biologically and medicinally relevant compounds.