Regioselective One-Pot Protection of d-Glucosamine

Chang, Ken-Lien; Manuel L. Zulueta, Medel; Lu, Xin-An; Zhong, Yong-Qing; Hung, Shang-Cheng

doi:10.1021/jo101320r.s001

jo101320r_si_001.pdf (5.97 MB)

Regioselective One-Pot Protection of d-Glucosamine

journal contribution

posted on 2010-11-05, 00:00 authored by Ken-Lien Chang, Medel Manuel L. Zulueta, Xin-An Lu, Yong-Qing Zhong, Shang-Cheng Hung

A highly regioselective one-pot transformation of 2-azido-2-deoxy-1,3,4,6-tetra-O-trimethylsilyl-d-glucopyranose via sequential additions of various reagents was systematically studied, yielding the fully protected derivatives and the 1-, 3-, 4-, as well as 6-alcohols, respectively.