Regioselective Copper-Mediated Synthesis of Thieno[2,3-c]pyrane-7-one, Indolo[2,3-c]pyrane-1-one, and Indolo[3,2-c]pyrane-1-one

Ngi, Samuel Inack; Guilloteau, Vincent; Abarbri, Mohamed; Thibonnet, Jérôme

doi:10.1021/jo201528u.s001

Regioselective Copper-Mediated Synthesis of Thieno[2,3-c]pyrane-7-one, Indolo[2,3-c]pyrane-1-one, and Indolo[3,2-c]pyrane-1-one

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posted on 2011-10-21, 00:00 authored by Samuel Inack Ngi, Vincent Guilloteau, Mohamed Abarbri, Jérôme Thibonnet

In the presence of copper(I) iodide, heteroaromatic β-iodo-α,β-unsaturated carboxylic acid systems opposed to terminal alkyne afford selectively 6-endo-dig cyclization products via a tandem coupling oxacyclization reaction.

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Regioselective presence heteroaromatic Indolo carboxylic acid oxacyclization reaction iodide Synthesi Thieno tandem terminal alkyne iodo

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Regioselective Copper-Mediated Synthesis of Thieno[2,3-c]pyrane-7-one, Indolo[2,3-c]pyrane-1-one, and Indolo[3,2-c]pyrane-1-one

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