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Regioselective C−H Functionalization Directed by a Removable Carboxyl Group:  Palladium-Catalyzed Vinylation at the Unusual Position of Indole and Related Heteroaromatic Rings

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journal contribution
posted on 20.03.2008, 00:00 by Atsushi Maehara, Hayato Tsurugi, Tetsuya Satoh, Masahiro Miura
The palladium-catalyzed oxidative vinylation of indole-3-carboxylic acids with alkenes effectively proceeds via directed C−H functionalization and decarboxylation to produce the corresponding 2-vinylated indoles. Similarly, pyrrole-, furan-, and thiophenecarboxylic acids also undergo decarboxylative vinylation.