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Reductive Synthesis of Aminal Radicals for Carbon–Carbon Bond Formation

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journal contribution
posted on 21.02.2014, 00:00 by David A. Schiedler, Yi Lu, Christopher M. Beaudry
Aminal radicals were generated by reduction of the corresponding amidine or amidinium ion. The intermediate radicals participate in C–C bond-forming reactions to produce fully substituted aminal stereocenters. No toxic additives or reagents are required. More than 30 substrate combinations are reported, and chemical yields are as high as 99%.